The current paper proposes a practice-oriented framework of corporate strategic optionality (a realization of the antifragility principle), allowing the companies to grow and thrive under the uncertain, multi-scenario future. The findings from the study provide practical guidance for corporate strategic leaders (board members and senior executives) with respect to getting ready to take advantage of environmental jolts (e.g., pandemics, crises, disruptions in the marketplace). The proposed framework complements the traditional risk management approaches, allowing to move from protecting from the downside towards thriving on the upside of strategic uncertainty.