The business landscape is constantly changing. Today’s leading companies face accelerating environmental turbulence and tectonic shifts in societal perceptions of private enterprise, of which the COVID-19 pandemic is neither the first nor the last major disruption in the history of unwanted events. The biggest challenge for businesses is to keep on evolving fast enough to remain relevant, while the greatest threat is to get stuck with what worked in the past. The article summarizes the body of rigorous academic literature on entrepreneurial strategies (effectuation, bricolage, pivoting, ambidexterity) effective in the turbulent environmental conditions of the VUCA (Volatility, Uncertainty, Complexity, and Ambiguity) world. The provided evidence-based advice is intended to help the managers to take the driver’s seat, proactively leading and shaping the future of their companies amidst environmental turbulence.